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Cytarabine

Cat. No. M2292
Cytarabine Structure
Synonym:

Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 36  USD40 In stock
100mg USD 49.5  USD55 In stock
500mg USD 94.5  USD105 In stock
1g USD 112.5  USD125 In stock
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Quality Control
Biological Activity

Cytarabine is an antimetabolic agent and a DNA polymerase with an IC50 of 16 nM for wild-type CCRF-CEM cells.Cytarabine is used mainly in the treatment of hematological malignancies such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. Cytarabine also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 243.22
Formula C9H13N3O5
CAS Number 147-94-4
Purity >99%
Solubility Water 34 mg/mL
Storage at -20°C
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Keywords: Cytarabine, Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C supplier, DNA/RNA Synthesis, inhibitors

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