DNA/RNA Synthesis DNA/RNA Synthesis

Cat.No.	Name	Information
M4879	Cycloheximide	Cycloheximide (Naramycin A) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Cycloheximide binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Cycloheximide suppresses ferroptosis and inhibits autophagy.
M2129	Temozolomide	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223	Cisplatin	Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289	5-Fluorouracil	5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M2288	Carboplatin	Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2292	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M1716	Gemcitabine Hydrochloride	Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M5680	Gemcitabine	Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M7515	Brivudine	Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M3955	Nedaplatin	Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.
M3898	YK-4-279	YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts.
M3892	BMH-21	BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo.
M3756	Oncrasin-1	Oncrasin-1 is a small molecule RNA polymerase II inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations.
M3746	Cyclophosphamide	Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. *The compound is unstable in solutions, freshly prepared is recommended
M3742	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. *The compound is unstable in solutions, freshly prepared is recommended
M3661	Chlorambucil	Chlorambucil is a nitrogen mustard alkylating agent which is mainly used in the treatment of chronic lymphocytic leukemia.
M3603	Procarbazine hydrochloride	Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
M3379	Trifluridine	Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection.
M3291	Hydroxyurea	Hydroxyurea (NSC-32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
M3229	PR-104A	PR-104A is a corresponding alcohol that is systemically converted from PR-104 and a hypoxia-targeted anticancer agent with IC50 of 153 and 60 μM for wild-type CHO AA8 under aerobic and anoxic conditions.
M3214	Adenine hydrochloride	Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3196	CCT239065	CCT239065 is a novel and selective BRAF^V600E and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
M2713	Foscarnet Sodium	Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
M2607	Ametantrone	Ametantrone induces interstrand DNA cross-links in HeLa S3 cells.
M2541	CRT0044876	CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
M2327	Daunorubicin hydrochloride	Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic.
M2224	Raltitrexed	Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy.
M1921	Mizoribine	Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively.
M1916	Nelarabine	Nelarabine is a novel purine antimetabolite antineoplastic agent.

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