Cat.No. | Name | Information |
---|---|---|
M4879 | Cycloheximide | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. |
M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
M2289 | 5-fluorouracil | 5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
M5680 | Gemcitabine | Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
M2224 | Raltitrexed | Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
M1921 | Mizoribine | Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. |
M1916 | Nelarabine | Nelarabine is a novel purine antimetabolite antineoplastic agent. |
M1698 | Clofarabine | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
M54506 | DTP3 TFA | DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. |
M53355 | Mating Factor α (1-6) | Mating Factor α (1-6) is a mating factor produced by α-mating type cells of Saccharomyces cerevisiae and an acts as an inhibitor of the initiation of DNA synthesis in the cells. |
M53354 | Polynucleotide kinase | Polynucleotide Kinase is a DNA repair enzyme. |
M53353 | Tetrapeptide | Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. |
M50222 | Branaplam hydrochloride | Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM. |
M49842 | Werner syndrome RecQ helicase-IN-3 | Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity. |
M49841 | Werner syndrome RecQ helicase-IN-4 | Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity. |
M49840 | Werner syndrome RecQ helicase-IN-2 | Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research. |
M49839 | Werner syndrome RecQ helicase-IN-1 | Werner syndrome RecQ helicase-IN-1 (HRO761) is a potentially first-in-class, potent inhibitor of Werner syndrome RecQ DNA deconjugase (WRN) for cancer research. |
M44721 | 3-Hydroxy-2-methylpyridine | 3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine. |
M43833 | DMT-dT-CE | DMT-dT-CE is typically used in the synthesis of DNA. |
M43832 | DMT-dC(Ac)-CE | DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. |
M43831 | DMT-dC(Bz)-CE | DMT-dC(Bz)-CE is typically used in the synthesis of DNA. |
M43830 | DMT-dG(dmf)-CE | DMT-dG(dmf)-CE is a phosphinamide monomer that can be used in the preparation of oligonucleotides. |
M43829 | DMT-dG(iBu)-CE | DMT-dG(iBu)-CE is typically used in the synthesis of DNA. |
M43828 | DMT-dA(Bz)-CE | DMT-dA(Bz)-CE is typically used in the synthesis of DNA. |
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