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DNA/RNA Synthesis DNA/RNA Synthesis

Cat.No.  Name Information
M4879 Cycloheximide Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M2129 Temozolomide Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223 Cisplatin Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289 5-fluorouracil 5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M2288 Carboplatin Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2292 Cytarabine Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M1716 Gemcitabine Hydrochloride Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M5680 Gemcitabine Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
M5277 B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M7515 Brivudine Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M2224 Raltitrexed Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy.
M1921 Mizoribine Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.
M1916 Nelarabine Nelarabine is a novel purine antimetabolite antineoplastic agent.
M1698 Clofarabine Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
M54506 DTP3 TFA DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
M53355 Mating Factor α (1-6) Mating Factor α (1-6) is a mating factor produced by α-mating type cells of Saccharomyces cerevisiae and an acts as an inhibitor of the initiation of DNA synthesis in the cells.
M53354 Polynucleotide kinase Polynucleotide Kinase is a DNA repair enzyme.
M53353 Tetrapeptide Tetrapeptide, an analogue of α-MSH, induces melanin synthesis.
M50222 Branaplam hydrochloride Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM.
M49842 Werner syndrome RecQ helicase-IN-3  Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity.
M49841 Werner syndrome RecQ helicase-IN-4  Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.
M49840 Werner syndrome RecQ helicase-IN-2  Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.
M49839 Werner syndrome RecQ helicase-IN-1  Werner syndrome RecQ helicase-IN-1 (HRO761) is a potentially first-in-class, potent inhibitor of Werner syndrome RecQ DNA deconjugase (WRN) for cancer research.
M44721 3-Hydroxy-2-methylpyridine 3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine.
M43833 DMT-dT-CE DMT-dT-CE is typically used in the synthesis of DNA.
M43832 DMT-dC(Ac)-CE DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
M43831 DMT-dC(Bz)-CE DMT-dC(Bz)-CE is typically used in the synthesis of DNA.
M43830 DMT-dG(dmf)-CE DMT-dG(dmf)-CE is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
M43829 DMT-dG(iBu)-CE DMT-dG(iBu)-CE is typically used in the synthesis of DNA.
M43828 DMT-dA(Bz)-CE DMT-dA(Bz)-CE is typically used in the synthesis of DNA.




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