Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. Procarbazine interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis. Procarbazine hydrochloride (Matulane) is used in the treatment of Hodgkin’s lymphoma and other malignant lymphomas including:- lymphosarcoma- reticulosarcoma- Brill-Symmers disease. Because procarbazine hydrochloride (Matulane) works differently to other anticancer agents,Procarbazine hydrochloride (Matulane) may be useful in the treatment of cancers that have not responded to other treatments.
| Molecular Weight | 257.76 |
| Formula | C12H19N3O.HCl |
| CAS Number | 366-70-1 |
| Solubility (25°C) | Water 50 mg/mL Ethanol 50mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] National Toxicology Program. Procarbazine and its hydrochloride
[2] No authors listed. Rep Carcinog. Procarbazine hydrochloride
[4] National Toxicology Program. Procarbazine hydrochloride
[5] No authors listed. IARC Monogr Eval Carcinog Risk Chem Hum. Procarbazine hydrochloride
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