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Trifluridine is an anti-herpesvirus antiviral agent, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors.
| Molecular Weight | 296.2 |
| Formula | C10H11F3N2O5 |
| CAS Number | 70-00-8 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL Water 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Akihito Kawazoe, et al. Trifluridine/tipiracil for the treatment of metastatic gastric cancer
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