DNA/RNA Synthesis DNA/RNA Synthesis

Cat.No.	Name	Information
M2129	Temozolomide	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223	Cisplatin	Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289	5-Fluorouracil	5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M2288	Carboplatin	Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2292	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M1716	Gemcitabine Hydrochloride	Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M5680	Gemcitabine	Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M7515	Brivudine	Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M9650	Triazavirin	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments.
M11539	PCNA-I1	Pcna-i1 is an effective PCNA (proliferating cell nuclear antigen) inhibitor. Pcna-i1 can selectively bind PCNA trimers, and its Kd value ranges from 0.2 μM to 0.4 μM. Pcna-i1 inhibited the growth of tumor cells with an IC50 value of ~0.2 μM.
M11535	RG7800	RG7800 is a small molecule SMN2 splicing modifier. RG7800 has the potential to be used in spinal muscular atrophy. RG7800 corrects selective splicing of the human SMN2 gene in the brain of a transgenic SMA model mouse, leading to an increase in SMN protein in the brain.
M11527	BCH001	BCH001 is a quinoline derivative and a selective PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in pluripotent stem cells induced by congenital keratosis (DC). BCH001 did not inhibit poly (A) -specific ribonucase (PARN) or several other polynucleotide polymerases. PAPD5 is A nonnormalized Poly (A) polymerase with an unconventional RNA binding motif.
M11341	Tempo	Tempo is a free radical capturing antioxidant and a selective scavenging agent of ROS that disambiguates superoxides in catalytic cycles. Tempo can induce DNA strand breaking and can be used as an organic catalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects.
M11056	NSC 617145	NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor,IC50 The value is 230 nM. NSC 617145 inhibit WRN ATPase and induce double-strand rupture (DSB) and chromosomal abnormalities. NSC 617145 is selective to WRN and superior to BLM, FANCJ, ChlR1, RecQ, and UvrD helicases.
M10693	H3B-8800	H3B-8800 is an orally available small molecule modulator of splicing factor 3B subunit 1 (SF3B1). H3B-8800 binds SF3B1 and exhibits significant antitumor activity by eliminating disruption of mRNA splicing.
M10612	4-Nitroquinoline N-oxide	4-Nitroquinoline N-oxide (4-NQO) corrects DNA damage through nucleotide excision repair. 4NQO may induce DNA damage by generating reactive oxygen species thought to be produced by the enzymatic reduction of its nitro group.
M10561	IMP-1088	IMP-1088 is a novel potent and selective blocker of N-myristoylation in cells. IMP-1088 is also a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2.
M10506	RK-33	RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity.
M10362	Beaucage reagent	Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers.
M10128	L189	L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively.
M10080	Saccharin 1-methylimidazole	Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis.
M10037	Lurbinectedin	Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity.
M9970	N-Nitrosodiethylamine (NDEA)	N-Nitrosodiethylamine (NDEA) belongs to the nitrosamines category of nitrogenous disinfection byproduct.
M9924	Risdiplam	Risdiplam (also known as RG7916 and RO7034067) is a gene splicing modulator (neuromuscular disease) that distributes into the central nervous system (CNS) and peripheral tissues.
M9860	Bleomycin A5 Hydrochloride	Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells.
M9506	TH5487	TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM.
M9270	COH29	COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.
M9262	Plicamycin	Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin has antineoplastic activity.
M9214	GC7 Sulfate	GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

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