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O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity.
| Molecular Weight | 241.25 |
| CAS Number | 19916-73-5 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 2-8°C, protect from light |
[3] Henry S Friedman, et al. Mol Cancer Ther. O6-benzylguanine-mediated enhancement of chemotherapy
[5] M E Dolan, et al. Clin Cancer Res. O6-benzylguanine and its role in chemotherapy
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