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Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
| Molecular Weight | 414.68 |
| CAS Number | 55837-20-2 |
| Solubility (25°C) | DMSO 20 mg/mL (ultrasonic and adjust pH to 5 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yin Luo, et al. J Leukoc Biol. The role of halofuginone in fibrosis: more to be explored?
[4] Mark Pines, et al. Molecules. Halofuginone - the multifaceted molecule
[5] Mark Pines, et al. Histol Histopathol. Halofuginone and muscular dystrophy
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