Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
Molecular Weight | 151.13 |
Formula | C5H5N5O |
CAS Number | 73-40-5 |
Solubility (25°C) | 1 M NaOH: 0.1 M DMSO 0.15 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related DNA/RNA Synthesis Products |
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3-Hydroxy-2-methylpyridine
3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine. |
DMT-dT-CE
DMT-dT-CE is typically used in the synthesis of DNA. |
DMT-dC(Ac)-CE
DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. |
DMT-dC(Bz)-CE
DMT-dC(Bz)-CE is typically used in the synthesis of DNA. |
DMT-dG(dmf)-CE
DMT-dG(dmf)-CE is a phosphinamide monomer that can be used in the preparation of oligonucleotides. |
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