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Guanine

Cat. No. M13646
Guanine Structure
Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 57  USD57 In stock
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Quality Control & Documentation
Biological Activity

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

Chemical Information
Molecular Weight 151.13
Formula C5H5N5O
CAS Number 73-40-5
Solubility (25°C) 1 M NaOH: 0.1 M
DMSO 0.15 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ping Qi, et al. Langmuir. Guanine Analogue-Based Assemblies: Construction and Luminescence Functions

[2] Vladimir Shafirovich, et al. Int J Mol Sci. Excision of Oxidatively Generated Guanine Lesions by Competitive DNA Repair Pathways

[3] Katsuhito Kino, et al. Int J Mol Sci. Products of Oxidative Guanine Damage Form Base Pairs with Guanine

[4] Nicholas J Thornton, et al. Int J Mol Sci. Halogen-Bonded Guanine Base Pairs, Quartets and Ribbons

[5] Lara Martnez-Fernndez, et al. Photochem Photobiol Sci. Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives

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Keywords: Guanine supplier, DNA/RNA Synthesis, inhibitors, activators


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