About 13 results found for searched term "Guanine" (0.115 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2414 | Azaguanine-8 | Others |
| Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. | ||
| M3258 | Thioguanine | DNA/RNA Synthesis |
| 6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol | ||
| Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. | ||
| M5332 | NU2058 | CDK |
| NU-2058; O6-(Cyclohexylmethyl)guanine | ||
| NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1. | ||
| M8703 | 8-Aminoguanine | Others |
| 8-amino-guanine, a guanine derivative, is an orally effective potassium-conserving diuretic/sodium compound that increases sodium excretion by 17.2 times and reduces potassium excretion by 71.0%. | ||
| M13473 | 2-(Methylamino)-1H-purin-6(7H)-one | Antibiotic |
| N2-methylguanine | ||
| 2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids. | ||
| M13646 | Guanine | DNA/RNA Synthesis |
| Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. | ||
| M13651 | O6-Benzylguanine | DNA/RNA Synthesis |
| O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. | ||
| M13698 | 5-Aza-7-deazaguanine | Others |
| 5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides. | ||
| M14340 | 2'-Deoxyguanosine | Metabolite/Endogenous Metabolite |
| Deoxyguanosine; Guanine deoxyriboside | ||
| 2'-Deoxyguanosine (Deoxyguanosine) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. | ||
| M38939 | 6-Chloroguanineriboside | Nucleoside Antimetabolite/Analog |
| 6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||
| M38941 | Isoguanine | Nucleoside Antimetabolite/Analog |
| Isoguanine is a purine base that is an isomer of Guanine. A building block in organic synthesis. | ||
| M42929 | 9-Deazaguanine | Others |
| 9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP). | ||
| M56646 | 8-Hydroxyguanine hydrochloride | Metabolite/Endogenous Metabolite |
| 8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. | ||
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