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8-Aminoguanine

Cat. No. M8703

All AbMole products are for research use only, cannot be used for human consumption.

8-Aminoguanine Structure

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Quality Control & Documentation
Biological Activity

8-amino-guanine, a guanine derivative, is an orally effective potassium-conserving diuretic/sodium compound that increases sodium excretion by 17.2 times and reduces potassium excretion by 71.0%. 8-amino guanine increased glucose excretion 12.1 times. In addition, 8-aminoguanine inhibits deoxycorticosterone/salt-induced hypertension.

Chemical Information
Molecular Weight 166.14
Formula C5H6N6O
CAS Number 28128-41-8
Solubility (25°C) 0.1 M NaOH: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Edwin K Jackson, et al. 8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1

[2] Edwin K Jackson, et al. 8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects

[3] Edwin K Jackson, et al. 8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity

[4] R Soliva, et al. DNA-triplex stabilizing properties of 8-aminoguanine

[5] R S Sodum, et al. 8-Aminoguanine: a base modification produced in rat liver nucleic acids by the hepatocarcinogen 2-nitropropane

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Keywords: 8-Aminoguanine supplier, inhibitors, activators

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