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Inhibitors

Cat.No.  Name Information
M2497 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
M5083 β-Cyclodextrin β-Cyclodextrin affects the formation of isomerization products during peptide deamidation.
M2189 MLN4924 MLN4924 is a novel small molecule NAE inhibitor with IC50 of 4 nM.
M8974 ALW-II-41-27 ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor with an IC50 of 11 nM for EPHA2.
M5708 Iohexol Iohexol is a contrast agent which can be applied for myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging in vivo.
M21544 4-Biphenylboronic acid 4-Biphenylboronic acid is a boric acid compound.
M21542 Deoxyribonucleic acid sodium salt from salmon testes Salmon refined deoxyribonucleic acid (SS-DNA) can be used to study the physical and chemical interactions of DNA with binders, inserters, modifiers, detection agents and densifiers. Salmon extract DNA was used to investigate the loading capacity of magnetic mesoporous silica nanoparticles (M-MSNs) and the bonding capacity of polymer nanolayer structures. SS-DNA can be used as a substrate for developing DNA detection methods.
M21541 L-2-Aminooxy-3-phenylpropanoic acid L-2-Aminooxy-3-phenylpropanoic acid is an inhibitor of L-phenylalanine ammonia-lyase.
M21538 Diphenyl diselenide Diphenyl diselenide inhibits δ-aminolevulinic acid dehydrase (δ-ALA-D) in brain, liver, and kidney in vivo.
M21536 BAY-069 BAY-069 is a branched-chain amino acid transaminase (BCAT) 1/2 inhibitor. Involved in the synthesis and catabolism of branched-chain amino acids.
M21535 UCB7362 UCB7362 is an oral plasma protease X (PMX) inhibitor that is being developed as an anti-malarial compound.
M21534 AN15368 AN15368 is an oral cleavage and polyadenylate specific factor (CPSF3) inhibitor being developed for use in Chagas disease (also known as American trypanosomiasis).
M21532 JNJ-64264681 JNJ-64264681 is a covalent Bruton tyrosine kinase (BTK) inhibitor under development for hematological malignancies.
M21528 1-Carbamoylcyclopropanecarboxylic acid
M21527 MES hydrate MES is a buffer solution. MES is an amphoteric ion N- substituted sulfamic acid with a morpholine ring. This composition does not form complexes with most metals used in environmental and biological research. It is soluble in water but extremely insoluble in lipids, and therefore unable to penetrate membranes.
M21511 RGLS4326 RGLS4326 (RG4326) is a first-in-class microRNA-17 (miR-17) oligonucleotide inhibitor. RGLS4326 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 acts on HeLa cells to inhibit the function of miR-17 with EC50 value of 28.3 nM.
M21510 Telaglenastat hydrochloride Telaglenastat (CB-839) hydrochloride is a pioneering (first-in-class), selective, reversible, orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride has IC50 values of 23 nM and 28 nM for endogenous glutaminase in the kidney and brain of mice, respectively. Telaglenastat hydrochloride also induces autophagy and has strong antitumor activity.
M21508 Ibezapolstat Ibezapolstat (ACX-362E) is a first-of-its-kind (first-in-class) inhibitor of the orally active DNA polymerase IIIC (DNA pol IIIC) developed for use in the study of Clostridium difficile infection (CDI).
M21502 FBA-IN-1 FBA-IN-1 is a pioneer, covalent allosteric inhibitor of 1, 6-bisphosphate fructoalbinase (CaFBA) from Candida albicans. FBA-IN 1 inhibited the growth of azole resistant strain 103 with MIC80 of 1 μg/mL.
M21501 Monalizumab Monalizumab is a first-in-class immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab can be used in the study of head and neck squamous cell carcinoma (HNSCC).
M21499 Rodatristat ethyl Rodatristat ethyl (KAR5585) was a first-in-class inhibitor of tryptophan hydroxylase 1 (TPH1) with oral activity.
M21497 Gemcabene calcium Gemcabene calcium (PD-72953 calcium), the pioneering (first-in-class) lipid-lowering agent, can lower density lipoprotein cholesterol (LDL-C), lower triglycerides, and increase high-density lipoprotein cholesterol (HDL-C), and lower pro-inflammatory acute phase proteins. C-reactive protein (CRP), which shows anti-inflammatory activity.
M21494 Sibofimloc Sibofimloc (CD-202) is a first-in-class, intestinal limiting and oral active inhibitor of FimH adhesion. Sibofimloc has antibacterial activity and is being developed for the study of inflammatory bowel disease (IBD).
M21493 Omadacycline mesylate Omadacycline (PTK 0796) mesylate, the first (first-in-class) orally active aminomethylcycline antibiotic, is a tetracycline antibiotic. Omadacycline mesylate can be used to study acute bacterial skin and skin structure infections, infectious pneumonia, and urinary tract infections.
M21492 Omadacycline Omadacycline (PTK 0796) tosylate, the first (first-in-class) orally active aminomethylcycline antibiotic, is a tetracycline antibiotic. Omadacycline tosylate can be used to study acute bacterial skin and skin structure infections, infectious pneumonia, and urinary tract infections.



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