EGTA is a specific calcium chelator with a Kd of 60.5 nM at physiological pH (7.4) and a high specificity for Ca2+ than for Mg2+. EGTA significantly inhibits the substrate adhesion capacity of inflammatory macrophages.
Ann Hematol. 2022 Oct;101(10):2195-2208.
CD277 agonist enhances the immunogenicity of relapsed/refractory acute myeloid leukemia towards Vδ2 + T cell cytotoxicity
EGTA purchased from AbMole
Cell Death Dis. 2021 Feb 15;12(2):179.
Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
EGTA purchased from AbMole
| Molecular Weight | 380.35 |
| Formula | C14H24N2O10 |
| CAS Number | 67-42-5 |
| Solubility (25°C) | Soluble in 0.1M NaOH |
| Storage | RT, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Laurel Oldach. Democratizing calcium visualization
[2] D Tripodi, et al. Demineralizing action of EGTA in endodontics
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