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5-Aza-7-deazaguanine

Cat. No. M13698

All AbMole products are for research use only, cannot be used for human consumption.

5-Aza-7-deazaguanine Structure

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Biological Activity

5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.

Chemical Information
Molecular Weight 151.13
CAS Number 67410-64-4
Solubility (25°C) Water 5 mg/mL (ultrasonic and adjust pH to 9 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dasharath Kondhare, et al. J Org Chem. DNA with Purine-Purine Base Pairs: Size and Position of Isoguanine and 8-Aza-7-deazaisoguanine Clickable Residues Control the Molecular Recognition of Guanine and 5-Aza-7-deazaguanine

[2] Aigui Zhang, et al. Chemistry. 5-Aza-7-deazaguanine-Isoguanine and Guanine-Isoguanine Base Pairs in Watson-Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains, and Pyrene Adducts

[3] Dasharath Kondhare, et al. J Org Chem. Alkynylated and Dendronized 5-Aza-7-deazaguanine Nucleosides: Cross-Coupling with Tripropargylamine and Linear Alkynes, Click Functionalization, and Fluorescence of Pyrene Adducts†

[4] Dasharath Kondhare, et al. Acta Crystallogr C Struct Chem. 7-Iodo-5-aza-7-deazaguanine ribonucleoside: crystal structure, physical properties, base-pair stability and functionalization

[5] Peter Leonard, et al. J Org Chem. Nucleobase-Functionalized 5-Aza-7-deazaguanine Ribo- and 2'-Deoxyribonucleosides: Glycosylation, Pd-Assisted Cross-Coupling, and Photophysical Properties

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