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Cat. No. M9650
Triazavirin Structure

Riamilovir sodium dihydrate

Size Price Availability Quantity
5mg USD 402.3  USD447 In stock
10mg USD 670.5  USD745 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture. 

In high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 286.20
Formula C5H7N6NaO5S
CAS Number 928659-17-0
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C

Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drv g Triazavirin
Ksenia V Kozhikhova, et al. Pharm Dev Technol. 2018 Apr;23(4):334-342. PMID: 27681534.

Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice
S Ya Loginova, et al. Antibiot Khimioter. 2015;60(7-8):11-3. PMID: 26863736.

Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture
S Ia Loginova, et al. Antibiot Khimioter. 2014;59(1-2):3-5. PMID: 25051708.

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Keywords: Triazavirin, Riamilovir sodium dihydrate supplier, DNA/RNA Synthesis, inhibitors

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