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Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
Phytomedicine. 2024 Apr 21.
Dihydrotanshinone I inhibits gallbladder cancer growth by targeting the Keap1-Nrf2 signaling pathway and Nrf2 phosphorylation
Gemcitabine purchased from AbMole
Oncol Lett. 2022 May;23(5):163.
AK4P1 is a cancer-promoting pseudogene in pancreatic adenocarcinoma cells whose transcripts can be transmitted by exosomes
Gemcitabine purchased from AbMole
Int J Oncol. 2020 Jan;56(1):47-68.
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?
Gemcitabine purchased from AbMole
Biosci Rep. 2020 Jul 31;40(7):BSR20200730.
NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway
Gemcitabine purchased from AbMole
Biosci Rep. 2020 Jul 31;40(7):BSR20200730.
NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway
Gemcitabine purchased from AbMole
Universitat Freiburg im Breisgau. 2020 Jul.
Investigation of chemotherapy-induced non-coding RNA expression alterations in clinical breast cancer management
Gemcitabine purchased from AbMole
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Source | Biosci Rep (2020), Figure 2, Gemcitabine (Abmole Bioscience) |
| Method | MTT assay for cell cytotoxicity | |
| Cell Lines | TNBC cell lines | |
| Concentrations | 0, 1, 3, 5 nm | |
| Incubation Time | 48 h | |
| Results | Next, the cytotoxicity in each group was monitored with MTT when the cells were treated with 0, 1, 3 and 5 nm gemcitabine and findings tended to prove that agonized NLRP3 could better resist the inhibitory effect of growing gemcitabine, in other words, higher expression of NLRP3 decreased the cytotoxicity and added to the gemcitabine resistance while inhibition of NLRP3 increased cytotoxicity in TNBCC, helping to alleviate the drug resistance |
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Source | Biosci Rep (2020), Figure 1, Gemcitabine (Abmole Bioscience) |
| Method | Cell culture and treatment | |
| Cell Lines | TNBC cell lines | |
| Concentrations | 0, 1, 3, 5 nM | |
| Incubation Time | 72 h | |
| Results | The linear graph presented the cytotoxicity at 72 h when exposed to different concentrations. It showed that highest cell viability was seen in agonist group with higher NLRP3 and lowest in antagonist group, suggesting that the higher expression of NLRP3, the less sensitive to different gemcitabine doses |
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Source | Bioscience Reports (2020 Jul). Figure 1. Gemcitabine (Abmole Bioscience) |
| Method | Cell culture | |
| Cell Lines | TNBC cell lines | |
| Concentrations | 0, 1, 3, 5 nM | |
| Incubation Time | 72 h | |
| Results | It showed that highest cell viability was seen in agonist group with higher NLRP3 and lowest in antagonist group, suggesting that the higher expression of NLRP3, the less sensitive to different gemcitabine doses |
| Molecular Weight | 263.2 |
| Formula | C9H11F2N3O4 |
| CAS Number | 95058-81-4 |
| Solubility (25°C) | DMSO 120 mg/mL |
| Storage | -20°C, protect from light, sealed |
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| Caf1-IN-1
Caf1-IN-1 is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM. |
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