About 13 results found for searched term "Gemcitabine" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1716 | Gemcitabine Hydrochloride | DNA/RNA Synthesis |
| Gemzar, LY-188011 | ||
| Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. | ||
| M5680 | Gemcitabine | DNA/RNA Synthesis |
| NSC 613327; LY188011 | ||
| Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. | ||
| M13701 | Gemcitabine elaidate | Others |
| CP-4126; CO-101; Gemcitabine 5'-elaidate | ||
| Gemcitabine elaidate (CP-4126) is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity. | ||
| M13702 | Gemcitabine elaidate hydrochloride | Others |
| CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride | ||
| Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity. | ||
| M8960 | LY2334737 | DNA/RNA Synthesis |
| LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. | ||
| M11418 | SAR-020106 | Checkpoint |
| Sar-020106 is an ATP-competitive and selective CHK1 inhibitor with an IC50 of 13.3 nM. Sar-020106 has good selectivity to CHK2. Sar-020106 increased cell lethality of Gemcitabine and SN38 by 3.0 to 29 times in a p53-dependent manner in several colon cancer cell lines. Sar-020106 can enhance antitumor activity by selecting anticancer drugs. | ||
| M13638 | Acelarin | DNA/RNA Synthesis |
| NUC-1031 | ||
| Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. | ||
| M27924 | GNE-900 | Checkpoint |
| GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. gemcitabine and GNE-900 administration shows anti-tumor activity. | ||
| M28944 | FF-10502 | Nucleoside Antimetabolite/Analog |
| FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells. | ||
| M29195 | Nastorazepide | Cholecystokinin Receptor |
| Z-360 | ||
| Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target：CCK-2 in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice. | ||
| M41200 | Viral polymerase-IN-1 hydrochloride | Anti-infection |
| Viral polymerase-IN-1 hydrochloride, a Gemcitabine derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. | ||
| M41547 | S-Gem | Nucleoside Antimetabolite/Analog |
| S-Gem is a TrxR-dependent precursor of Gemcitabine and selectively activated by TrxR. | ||
| M51738 | Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) | Others |
| Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) is a cyclic RGD peptide that serves as a conjugated multifunctional nanodrug delivery system to target Gemcitabine to pancreatic cancer cells. | ||
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