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Daunorubicin hydrochloride

Cat. No. M2327
Daunorubicin hydrochloride Structure

Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

Size Price Availability Quantity
5mg USD 30  USD30 In stock
10mg USD 46  USD46 In stock
25mg USD 84  USD84 In stock
50mg USD 133  USD133 In stock
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Quality Control & Documentation
Biological Activity

Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. 

Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis, with potent anti-tumor activity. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers. 

Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.

Chemical Information
Molecular Weight 563.98
Formula C27H29NO10.HCl
CAS Number 23541-50-6
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Lawrence D Mayer, et al. CPX-351: a nanoscale liposomal co-formulation of daunorubicin and cytarabine with unique biodistribution and tumor cell uptake properties

[2] He Lian, et al. Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy

[3] Beata Medenecka, et al. Stability of [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride in solid state

[4] Anna Krause, et al. Acid-base catalysis of N-[(morpholine)methylene]daunorubicin

[5] R M Stroshane. Production of daunorubicin

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Keywords: Daunorubicin hydrochloride, Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride supplier, DNA/RNA Synthesis, inhibitors, activators

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