Free shipping on all orders over $ 500

Daunorubicin hydrochloride

Cat. No. M2327
Daunorubicin hydrochloride Structure
Synonym:

Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

Size Price Availability Quantity
5mg USD 30  USD30 In stock
10mg USD 46  USD46 In stock
25mg USD 84  USD84 In stock
50mg USD 133  USD133 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. 

Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis, with potent anti-tumor activity. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers. 

Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.

Chemical Information
Molecular Weight 563.98
Formula C27H29NO10.HCl
CAS Number 23541-50-6
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lawrence D Mayer, et al. CPX-351: a nanoscale liposomal co-formulation of daunorubicin and cytarabine with unique biodistribution and tumor cell uptake properties

[2] He Lian, et al. Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy

[3] Beata Medenecka, et al. Stability of [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride in solid state

[4] Anna Krause, et al. Acid-base catalysis of N-[(morpholine)methylene]daunorubicin

[5] R M Stroshane. Production of daunorubicin

Related DNA/RNA Synthesis Products
Cy5-dATP

Cy5-dATP is a Cy5-labeled dATP that can be incorporated into DNA primers to amplify fluorescent Cy5DNA and can be used in T5 exonuclease (T5exo)-like DNAzyme assays.

Prunasin

Prunasin is a inhibitor of DNA Polymerase β.

Carbazole

Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA.

Rabdosin B

Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings.

Riddelline

Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.

  Catalog
Abmole Inhibitor Catalog




Keywords: Daunorubicin hydrochloride, Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride supplier, DNA/RNA Synthesis, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.