| Cat.No. | Name | Information |
|---|---|---|
| M4879 | Cycloheximide | Cycloheximide (Naramycin A) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Cycloheximide binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Cycloheximide suppresses ferroptosis and inhibits autophagy. |
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-Fluorouracil | 5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M41469 | DNA Gyrase-IN-8 | DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor with an IC50 value of 8.45 µM. |
| M41468 | RdRP-IN-6 | RdRP-IN-6 inhibits RNA dependent-RNA polymerase (RdRp) with an IC90 value of 14.1 μM. |
| M41467 | Ara-ATP | Ara-ATP, a structural analog of ATP, inhibits poly(A) polymerase activity by competing with ATP. |
| M41466 | 3-Cyanovinylcarbazole phosphoramidite | 3-Cyanovinylcarbazole phosphoramidite is an antiviral agent that inhibits the synthesis of viral DNA. |
| M41465 | WRN inhibitor 2 | WRN inhibitor 2 is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC50 ≥ 7.0. |
| M41464 | EDTA dipotassium dihydrate | EDTA (Ethylenediaminetetraacetic acid) dipotassium dihydrate is anticoagulants, chelating heavy metal and relieve toxicity. |
| M41463 | H3B-968 | H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM), which acts function as helicase, ATPase, and exonuclease. |
| M41462 | WRN inhibitor 1 | WRN inhibitor 1 is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits WRN helicase domain activity. |
| M41461 | SRE-II | SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. |
| M41460 | DNA polymerase-IN-3 | DNA polymerase-IN-3 is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research. |
| M41459 | DNA polymerase-IN-2 | DNA polymerase-IN-2, a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research. |
| M41458 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity. |
| M41123 | DNA gyrase B-IN-3 | DNA gyrase B-IN-3 is a bacterial DNA gyrase B inhibitor (IC50: < 10 nM). |
| M40655 | Cy5-dATP | Cy5-dATP is a Cy5-labeled dATP that can be incorporated into DNA primers to amplify fluorescent Cy5DNA and can be used in T5 exonuclease (T5exo)-like DNAzyme assays. |
| M38924 | Prunasin | Prunasin is a inhibitor of DNA Polymerase β. |
| M38923 | Carbazole | Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA. |
| M38922 | Rabdosin B | Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings. |
| M38920 | γ-Amanitin | γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. |
| M38919 | Neoxanthin | Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions. |
| M38918 | Quinizarin | Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth. |
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