Free shipping on all orders over $ 500

Oncrasin-1

Cat. No. M3756
Oncrasin-1 Structure
Size Price Availability Quantity
10mg USD 120  USD120 In stock
50mg USD 540  USD540 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Oncrasin-1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Oncrasin-1 induces aggregation of PKCL in the nuclei and is proapoptotic. oncrasin-1 or its active analogues could be a novel class of anticancer agents, which effectively kill K-Ras mutant cancer cells.

Chemical Information
Molecular Weight 269.73
Formula C16H12ClNO
CAS Number 75629-57-1
Solubility (25°C) DMSO 39 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wu S, et al. J Med Chem. Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

[2] Guo W, et al. Mol Cancer Ther. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

[3] Guo W, et al. Cancer Res. Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota.

Related DNA/RNA Synthesis Products
DTP3 TFA

DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.

Mating Factor α (1-6)

Mating Factor α (1-6) is a mating factor produced by α-mating type cells of Saccharomyces cerevisiae and an acts as an inhibitor of the initiation of DNA synthesis in the cells.

Polynucleotide kinase

Polynucleotide Kinase is a DNA repair enzyme.

Tetrapeptide

Tetrapeptide, an analogue of α-MSH, induces melanin synthesis.

Branaplam hydrochloride

Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Oncrasin-1 supplier, DNA/RNA Synthesis, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.