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RNase L-IN-1

Cat. No. M41471
RNase L-IN-1 Structure
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Biological Activity

RNase L-IN-1 is an inhibitor of RNase L, or Ribonuclease L.

Chemical Information
Molecular Weight 542.67
Formula C27H35FN6O3S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Muralidharan Vandanashree et al. Methods Enzymol. Characterization of RNase J

[2] Jessica Sayers et al. Bioconjug Chem. Semisynthesis of Human Ribonuclease-S

[3] Cassandra Herbert et al. Biochemistry. Reactivity and Specificity of RNase T1, RNase A, and RNase H toward Oligonucleotides of RNA Containing 8-Oxo-7,8-dihydroguanosine

[4] Elio Pizzo et al. Gene. The success of the RNase scaffold in the advance of biosciences and in evolution

[5] Jana Christin Wiegard et al. RNA. Processing and decay of 6S-1 and 6S-2 RNAs in Bacillus subtilis

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Keywords: RNase L-IN-1 supplier, DNA/RNA Synthesis, inhibitors, activators

 
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