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DMT-dC(Ac)-CE

Cat. No. M43832
DMT-dC(Ac)-CE Structure
Synonym:

DMT-dC(ac) Phosphoramidite

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Quality Control & Documentation
Biological Activity

DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

Chemical Information
Molecular Weight 771.84
Formula C41H50N5O8P
CAS Number 154110-40-4
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: DMT-dC(Ac)-CE, DMT-dC(ac) Phosphoramidite supplier, DNA/RNA Synthesis, inhibitors, activators


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