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IMP-1088

Cat. No. M10561
IMP-1088 Structure
Synonym:

IMP1088

Size Price Availability Quantity
5mg USD 825  USD825 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

IMP-1088 is a novel potent and selective blocker of N-myristoylation in cells. IMP-1088 is also a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 453.53
Formula C25H29F2N5O
CAS Number 2059148-82-0
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Aurelie Mousnier, et al. Nat Chem. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IMP-1088, IMP1088 supplier, DNA/RNA Synthesis, inhibitors

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