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Beaucage reagent

Cat. No. M10362
Beaucage reagent Structure
Synonym:

3H-1,2-Benzodithiol-3-one-1,1-dioxide

Size Price Availability Quantity
10mM*1mL in DMSO USD 50  USD50 In stock
250mg USD 50  USD50 In stock
1g USD 90  USD90 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 200.23
Formula C7H4O3S2
CAS Number 66304-01-6
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Jiahui Zheng, et al. Org Biomol Chem. Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

[2] M Manoharan, et al. Org Lett. Allyl group as a protecting group for internucleotide phosphate and thiophosphate linkages in oligonucleotide synthesis: facile oxidation and deprotection conditions

[3] Q Xu, et al. Nucleic Acids Res. Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides

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  Catalog
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Keywords: Beaucage reagent, 3H-1,2-Benzodithiol-3-one-1,1-dioxide supplier, DNA/RNA Synthesis, inhibitors

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