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H3B-8800

Cat. No. M10693

All AbMole products are for research use only, cannot be used for human consumption.

H3B-8800 Structure
Size Price Availability Quantity
1mg USD 300  USD300 In stock
5mg USD 600  USD600 In stock
10mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

H3B-8800 is an orally available small molecule modulator of splicing factor 3B subunit 1 (SF3B1). H3B-8800 binds SF3B1 and exhibits significant antitumor activity by eliminating disruption of mRNA splicing.

Chemical Information
Molecular Weight 555.71
Formula C31H45N3O6
CAS Number 1825302-42-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder -20°C
References

[1] Bryan Oronsky, et al. Invest New Drugs. RRx-001, A novel dinitroazetidine radiosensitizer

[2] Kimberly J Jurgensen, et al. Front Pharmacol. RRx-001 Radioprotection: Enhancement of Survival and Hematopoietic Recovery in Gamma-Irradiated Mice

[3] Bryan Oronsky, et al. J Cancer Res Clin Oncol. RRx-001 protects against cisplatin-induced toxicities

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Keywords: H3B-8800 supplier, DNA/RNA Synthesis, inhibitors, activators

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