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H3B-8800

Cat. No. M11429
H3B-8800 Structure
Synonym:

H3B8800

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Quality Control
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  • Purity N/A
  • COA
  • MSDS
Biological Activity

An oral RNA splicing regulator targeting spliceosomal SF3b complex. By inhibiting the action of SF3b complex, tumor cells carrying spliceosomal mutations are more effectively killed.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 555.71
Formula C31H45N3O6
CAS Number 1825302-42-8
Purity N/A
Solubility N/A
Storage at -20°C
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Antide

Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

NE-CARBOXYMETHYL-L-LYSINE

NE-CARBOXYMETHYL-L-LYSINE

  Catalog
Abmole Inhibitor Catalog




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