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N-Nitrosodiethylamine (NDEA) belongs to the nitrosamines category of nitrogenous disinfection byproduct. N-Nitrosodiethylamine has been used to induce hepatocarcinogenesis in rat and mice. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
| Molecular Weight | 102.14 |
| Formula | C4H10N2O |
| CAS Number | 55-18-5 |
| Solubility (25°C) | Water 100 mg/mL DMSO 100 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
[1] Devy Maulidya Cahyani, et al. N-nitrosodiethylamine induces inflammation of liver in mice
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