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L189

Cat. No. M10128
L189 Structure
Synonym:

L-189

Size Price Availability Quantity
10mg USD 110  USD110 In stock
25mg USD 244  USD244 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 246.29
Formula C11H10N4OS
CAS Number 64232-83-3
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

[1] Xi Chen, et al. Cancer Res. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: L189, L-189 supplier, DNA/RNA Synthesis, inhibitors

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