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Saccharin 1-methylimidazole

Cat. No. M10080
Saccharin 1-methylimidazole Structure
Synonym:

SMI

Size Price Availability
50mg USD 210  USD210 4-7 Days
100mg USD 350  USD350 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 265.29
Formula C7H5NO3S.C4H6N2
CAS Number 482333-74-4
Purity >99%
Solubility DMSO 5 mg/mL
Storage at -20°C
References

[1] A L Boynton, et al. Cancer Res. Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Saccharin 1-methylimidazole, SMI supplier, DNA/RNA Synthesis, inhibitors

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