Free shipping on all orders over $ 500


Cat. No. M21600
Plitidepsin Structure


Size Price Availability Quantity
5mg USD 900  USD900 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research.

Chemical Information
Molecular Weight 1110.34
Formula C57H87N7O15
CAS Number 137219-37-5
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Michail Papapanou, et al. J Pers Med. Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19

[2] Kris M White, et al. Science. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

[3] No authors listed. Aust Prescr. Plitidepsin for multiple myeloma

[4] Michael Leisch, et al. Future Oncol. Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma

[5] Sara Alonso-lvarez, et al. Drug Des Devel Ther. Plitidepsin: design, development, and potential place in therapy

Related DNA/RNA Synthesis Products

DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.

Mating Factor α (1-6)

Mating Factor α (1-6) is a mating factor produced by α-mating type cells of Saccharomyces cerevisiae and an acts as an inhibitor of the initiation of DNA synthesis in the cells.

Polynucleotide kinase

Polynucleotide Kinase is a DNA repair enzyme.


Tetrapeptide, an analogue of α-MSH, induces melanin synthesis.

Branaplam hydrochloride

Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM.

Abmole Inhibitor Catalog

Keywords: Plitidepsin, Aplidine supplier, DNA/RNA Synthesis, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.