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Plitidepsin

Cat. No. M21600
Plitidepsin Structure
Synonym:

Aplidine

Size Price Availability Quantity
5mg USD 900  USD900 In stock
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Quality Control & Documentation
Biological Activity

Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research.

Chemical Information
Molecular Weight 1110.34
Formula C57H87N7O15
CAS Number 137219-37-5
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michail Papapanou, et al. J Pers Med. Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19

[2] Kris M White, et al. Science. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

[3] No authors listed. Aust Prescr. Plitidepsin for multiple myeloma

[4] Michael Leisch, et al. Future Oncol. Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma

[5] Sara Alonso-lvarez, et al. Drug Des Devel Ther. Plitidepsin: design, development, and potential place in therapy

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Keywords: Plitidepsin, Aplidine supplier, DNA/RNA Synthesis, inhibitors, activators


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