Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research.
|Solubility (25°C)||DMSO ≥ 60 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Michail Papapanou, et al. J Pers Med. Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19
 Kris M White, et al. Science. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
 No authors listed. Aust Prescr. Plitidepsin for multiple myeloma
 Michael Leisch, et al. Future Oncol. Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma
 Sara Alonso-lvarez, et al. Drug Des Devel Ther. Plitidepsin: design, development, and potential place in therapy
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