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Nemorubicin

Cat. No. M27770

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Nemorubicin Structure
Synonym:

Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243

Size Price Availability Quantity
5mg USD 132  USD132 In stock
10mg USD 240  USD240 In stock
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Biological Activity

Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity.

Chemical Information
Molecular Weight 643.64
Formula C32H37NO13
CAS Number 108852-90-0
Form Solid
Solubility (25°C) DMSO 65 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matteo Scalabrin, et al. Chem Res Toxicol. Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA

[2] Leonardo Scaglioni, et al. Biochim Biophys Acta. Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22

[3] Massimo Broggini. Top Curr Chem. Nemorubicin

[4] Stefania Mazzini, et al. Bioorg Med Chem. The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs

[5] Luigi Quintieri, et al. Biochem Pharmacol. In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes

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Keywords: Nemorubicin, Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243 supplier, DNA/RNA Synthesis, inhibitors, activators

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