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Pyridostatin

Cat. No. M27767

All AbMole products are for research use only, cannot be used for human consumption.

Pyridostatin Structure
Synonym:

RR82

Size Price Availability Quantity
5mg USD 106  USD106 In stock
10mg USD 139  USD139 In stock
50mg USD 580  USD580 In stock
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Quality Control & Documentation
Biological Activity

Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.

Chemical Information
Molecular Weight 596.64
Formula C31H32N8O5
CAS Number 1085412-37-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Liu-Yi Liu, et al. J Am Chem Soc. Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes

[2] Yinzhu Hou, et al. Nucleic Acids Res. G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex

[3] Florian J Groelly, et al. EMBO Mol Med. Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours

[4] Min Zou, et al. Int J Biol Macromol. G-quadruplex binder pyridostatin as an effective multi-target ZIKV inhibitor

[5] Michele Olivieri, et al. Cell. A Genetic Map of the Response to DNA Damage in Human Cells

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Keywords: Pyridostatin, RR82 supplier, DNA/RNA Synthesis, inhibitors, activators

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