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ART812

Cat. No. M21558

All AbMole products are for research use only, cannot be used for human consumption.

ART812  Structure
Size Price Availability Quantity
5mg USD 630  USD630 In stock
10mg USD 970  USD970 In stock
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Quality Control & Documentation
Biological Activity

ART812 is an orally effective DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 had an IC50 value of 240 nM for cell-based microhomologous mediated end-junction (MMEJ).

Chemical Information
Molecular Weight 461.79
Formula C19H16ClF4N3O4
CAS Number 2607138-82-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gabriela Barszczewska-Pietraszek, et al. Int J Mol Sci. Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

[2] Martin L Stockley, et al. J Med Chem. Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta

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  Catalog
Abmole Inhibitor Catalog




Keywords: ART812 supplier, DNA/RNA Synthesis, inhibitors, activators

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