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Xanthosine 5'-monophosphate sodium salt

Cat. No. M15058
Xanthosine 5'-monophosphate sodium salt Structure
Synonym:

5'-Xanthylic acid sodium salt

Size Price Availability Quantity
50mg USD 107  USD107 In stock
100mg USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

Xanthine 5' -monophosphate (XMP) is an intermediate of purine metabolism and a product of rate-limiting step in guanosine production, which plays an important role in the synthesis of DNA, RNA and glycoproteins. XMP is produced by inosin-5 '-monophosphate via IMP dehydrogenase (IMPDH). IMPDH inhibitors, including ribavirin and myophenolate, have potential applications as antiviral and anticancer compounds.

Chemical Information
Molecular Weight 408.17
Formula C10H11N4Na2O9P
CAS Number 25899-70-1
Form Solid
Solubility (25°C) Water ≥ 200 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Xanthosine 5'-monophosphate sodium salt, 5'-Xanthylic acid sodium salt supplier, DNA/RNA Synthesis, inhibitors, activators


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