Xanthine 5' -monophosphate (XMP) is an intermediate of purine metabolism and a product of rate-limiting step in guanosine production, which plays an important role in the synthesis of DNA, RNA and glycoproteins. XMP is produced by inosin-5 '-monophosphate via IMP dehydrogenase (IMPDH). IMPDH inhibitors, including ribavirin and myophenolate, have potential applications as antiviral and anticancer compounds.
|Solubility (25°C)||Water ≥ 200 mg/mL|
|Storage||4°C, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related DNA/RNA Synthesis Products|
3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine.
DMT-dT-CE is typically used in the synthesis of DNA.
DMT-dC(Ac)-CE is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
DMT-dC(Bz)-CE is typically used in the synthesis of DNA.
DMT-dG(dmf)-CE is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
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