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Mitomycin C

Cat. No. M5791
Mitomycin C Structure

MMC; Ametycine

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
50mg USD 200  USD200 In stock
100mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis.

Product Citations
Customer Product Validations & Biological Datas
Source Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA)
Method Wound healing assays
Cell Lines human pancreatic cancer cells (Panc-1)
Concentrations 10 mg/mL
Incubation Time 12 h
Results Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay.
Chemical Information
Molecular Weight 334.37
Formula C15H18N4O5
CAS Number 50-07-7
Solubility (25°C) DMSO 50 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jieping Deng, et al. J Leukoc Biol. Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins

[2] Michelle Vang Mouritzen, et al. J Vis Exp . Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera

[3] Laura Dittmar, et al. Hum Immunol. Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro

[4] Rustagi T, et al. J Clin Gastroenterol. Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.

[5] Antonio Di Grazia, et al. Antimicrob Agents Chemother . Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus

[6] Christian Andreas Radu, et al. J Surg Res. Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation

[7] Weiwen Yang, et al. Int J Cancer. Kinetics of repression by modified p53 on the PDGF beta-receptor promoter

[8] Jeanho Yun, et al. Oncogene. Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest

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Keywords: Mitomycin C, MMC; Ametycine supplier, Animal Modeling, inhibitors, activators

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