Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis.
Immun Inflamm Dis. 2023 Sep;11(9):e1011.
Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein-α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice
Mitomycin C purchased from AbMole
Front Immunol. 2023 May 1;14:1182851.
Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival
Mitomycin C purchased from AbMole
Skin Res Technol. 2023 Feb;29(2):e13290.
The use of human‐derived feeder layers for the cultivation of transplantable human epidermal cell sheet to repair second degree burn wounds
Mitomycin C purchased from AbMole
Comput Math Methods Med. 2022 Jul 13;2022:2517463.
MicroRNA-424-5p Alleviates Isoflurane Anesthesia-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons by Targeting FASN
Mitomycin C purchased from AbMole
Biomed Res Int. 2021 Jun 10;2021:6616547.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway
Mitomycin C purchased from AbMole
Int J Mol Sci. 2020 Apr 30;21(9):3164.
Leukamenin E Induces K8/18 Phosphorylation and Blocks the Assembly of Keratin Filament Networks Through ERK Activation
Mitomycin C purchased from AbMole
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Source | Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA) |
| Method | Wound healing assays | |
| Cell Lines | human pancreatic cancer cells (Panc-1) | |
| Concentrations | 10 mg/mL | |
| Incubation Time | 12 h | |
| Results | Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay. |
| Molecular Weight | 334.37 |
| Formula | C15H18N4O5 |
| CAS Number | 50-07-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Animal Modeling Products |
|---|
| N-Butyl-N-(4-hydroxybutyl)nitrosamine
N-Butyl-N-(4-hydroxybutyl)nitrosamine can be used to construct animal models of bladder cancer (BLCA). |
| Boromycin
Boromycin is a compound isolated from Streptomyces antibioticus and a boron-containing macrolide antibiotic with potent activity against a number of viruses, gram-positive bacteria and protozoan parasites. It can be used to induce a mouse model of pulmonary fibrosis and can be used in malaria-related studies. |
| Dextrose iron
Dextrose iron can be used to construct animal models of iron overload. |
| Prednisone acetate
Prednisone acetate is the acetate form of Prednisone and a glucocorticoid receptor agonist with anti-inflammatory and immunomodulatory properties. It can be used to construct animal models of Kawasaki disease. |
| Carrageenan
Carrageenan is a biochemical reagent that can be used to construct animal models of chronic non-bacterial prostatitis, models of synovitis, and models of prostatitis. |
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