Free shipping on all orders over $ 500

Mitomycin C

Cat. No. M5791
Mitomycin C Structure


Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
50mg USD 200  USD200 In stock
100mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis.

Product Citations
Customer Product Validations & Biological Datas
Source Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA)
Method Wound healing assays
Cell Lines human pancreatic cancer cells (Panc-1)
Concentrations 10 mg/mL
Incubation Time 12 h
Results Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay.
Chemical Information
Molecular Weight 334.37
Formula C15H18N4O5
CAS Number 50-07-7
Solubility (25°C) DMSO 60 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Michelle Vang Mouritzen, et al. J Vis Exp . Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera

[2] Laura Dittmar, et al. Hum Immunol. Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro

[3] Rustagi T, et al. J Clin Gastroenterol. Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.

[4] Antonio Di Grazia, et al. Antimicrob Agents Chemother . Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus

[5] Christian Andreas Radu, et al. J Surg Res. Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation

[6] P L Leenaerts, et al. Transplantation. Evidence that stimulator cell-derived IL-6 and IL-1 are released in the mixed lymphocyte culture but are not requisite for responder T cell proliferation

Related DNA/RNA Synthesis Products

D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively.


Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain with IC50 of 74 nM. Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51.


Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research.


Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce SOD1 protein synthesis. Tofersen can be used in amyotrophic lateral sclerosis (ALS) research.


ART812 is an orally effective DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 had an IC50 value of 240 nM for cell-based microhomologous mediated end-junction (MMEJ).

Abmole Inhibitor Catalog

Keywords: Mitomycin C, MMC supplier, DNA/RNA Synthesis, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.