All AbMole products are for research use only, cannot be used for human consumption.
Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Eukaryotic cells respond to the presence of oxaliplatin adducts in DNA by activating signal transduction pathways that result in cell cycle arrest, an increase in DNA repair activity and apoptosis. Oxaliplatin was found to be active against C32 and G361 cell lines with IC50 values of 49.48 and 9.07 μM (1 h exposure), 9.47 and 1.30 μM (4 h exposure), and 0.98 and 0.14 μM (24 h exposure), respectively.
DMSO can inactivate Oxaliplatin's activity
Method for preparing solutions for intraperitoneal administration in rats and mice: Oxaliplatin was dissolved in a 5% glucose solution at a concentration of 2 mg/mL.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11247280/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3273641/
Iran J Pharm Res. 2025 Jul 21;24(1):e160886.
Cancer-Associated Fibroblasts Enhance Oxaliplatin Resistance in Colorectal Cancer Cells via Paracrine IL-6: An In Vitro Study
Oxaliplatin purchased from AbMole
Dokl Biochem Biophys. 2023 Oct.
Dichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells
Oxaliplatin purchased from AbMole
| Molecular Weight | 397.29 |
| Formula | C8H14N2O4Pt |
| CAS Number | 61825-94-3 |
| Solubility (25°C) | Water 3 mg/mL warmed DMF 1.6 mg/mL |
| Storage | 4°C, protect from light, sealed |
| Related DNA/RNA Synthesis Products |
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| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| CDDP
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| Raltitrexed
Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
| Carmofur
Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. |
| 5-Fluorouracil
5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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