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ACE-031 is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands. ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC(0-∞) and C(max) increased linearly with dose; mean T(½) was 10-15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism.
PLoS One. 2022 Sep 2;17(9):e0273193.
The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
ACE-031 (Myostatin inhibitory peptide 7) purchased from AbMole
| Molecular Weight | 2956.5 |
| Formula | C133H227N43O33 |
| CAS Number | 1621169-52-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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