ACE-031 is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands. ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC(0-∞) and C(max) increased linearly with dose; mean T(½) was 10-15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism.
PLoS One. 2022 Sep 2;17(9):e0273193.
The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
ACE-031 (Myostatin inhibitory peptide 7) purchased from AbMole
| Molecular Weight | 2956.5 |
| Formula | C133H227N43O33 |
| CAS Number | 1621169-52-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Peptides Products |
|---|
| Trypsin Inhibitor (from Soybean)
Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities. |
| (D-His2,D-Trp6)-LHRH
(D-His2,D-Trp6)-LHRH is a peptide that can be discovered by peptide screening. Peptide screening is a research tool that assembles active peptides primarily by immunoassay. It can be used for protein interactions, functional analysis, antigenic epitope screening, and the development and study of active molecules. |
| Ghrelin (mouse, rat) TFA
Ghrelin (mouse, rat) TFA is a gastrointestinal secretory-generated, endogenous brain-gut peptide consisting of 28 amino acids that possesses a variety of physiological functions including appetite stimulation, and is also an endogenous agonist peptide for the ghrelin (GHS) receptor. |
| LIP1 (human)
LIP1 (human) is a polypeptide produced from the anterior region of nerve growth factor (NGF) containing 29 amino acids that induces F-actin rearrangement, phosphorylates TrkA and Akt, and has antiproliferative as well as neuroprotective activities. Sequence: ARSAPAAAIAARVAGQTRNITVDPRLFKK |
| Kisspeptin-10, human ACETATE
Kisspeptin-10, human ACETATE is the acetate form of Kisspeptin-10 and is also a potent vasoconstrictor and angiogenesis inhibitor that inhibits tumor metastasis through its receptor GPR54.Kisspeptin-10/GPR54 signaling through NFATc4-mediated BMP2 expression to induces osteoblast differentiation through NFATc4-mediated BMP2 expression. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
