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ACE-031

Cat. No. M10203

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ACE-031 Structure
Synonym:

Myostatin inhibitory peptide 7

Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 475  USD475 In stock
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Quality Control & Documentation
Biological Activity

ACE-031 (Myostatin inhibitory peptide 7) is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands. ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC(0-∞) and C(max) increased linearly with dose; mean T(½) was 10-15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism.

Product Citations
Chemical Information
Molecular Weight 2956.5
Formula C133H227N43O33
CAS Number 1621169-52-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Craig Campbell, et al. Muscle Nerve. Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial

[2] Kenneth M Attie, et al. Muscle Nerve. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers

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Keywords: ACE-031, Myostatin inhibitory peptide 7 supplier, Peptides, inhibitors, activators

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