Elamipretide TFA, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide. Elamipretide alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. MTP-131 could prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2).
| Molecular Weight | 753.81 |
| Formula | C34H50F3N9O7 |
| CAS Number | 1606994-55-1 |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Peptides Products |
|---|
| Trypsin Inhibitor (from Soybean)
Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities. |
| (D-His2,D-Trp6)-LHRH
(D-His2,D-Trp6)-LHRH is a peptide that can be discovered by peptide screening. Peptide screening is a research tool that assembles active peptides primarily by immunoassay. It can be used for protein interactions, functional analysis, antigenic epitope screening, and the development and study of active molecules. |
| Ghrelin (mouse, rat) TFA
Ghrelin (mouse, rat) TFA is a gastrointestinal secretory-generated, endogenous brain-gut peptide consisting of 28 amino acids that possesses a variety of physiological functions including appetite stimulation, and is also an endogenous agonist peptide for the ghrelin (GHS) receptor. |
| LIP1 (human)
LIP1 (human) is a polypeptide produced from the anterior region of nerve growth factor (NGF) containing 29 amino acids that induces F-actin rearrangement, phosphorylates TrkA and Akt, and has antiproliferative as well as neuroprotective activities. Sequence: ARSAPAAAIAARVAGQTRNITVDPRLFKK |
| Kisspeptin-10, human ACETATE
Kisspeptin-10, human ACETATE is the acetate form of Kisspeptin-10 and is also a potent vasoconstrictor and angiogenesis inhibitor that inhibits tumor metastasis through its receptor GPR54.Kisspeptin-10/GPR54 signaling through NFATc4-mediated BMP2 expression to induces osteoblast differentiation through NFATc4-mediated BMP2 expression. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
