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Elamipretide TFA

Cat. No. M9137
Elamipretide TFA Structure

MTP-131; Bendavia; RX-31; SS-31

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 165  USD165 In stock
25mg USD 335  USD335 In stock
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Quality Control & Documentation
Biological Activity

Elamipretide TFA, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide. Elamipretide alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. MTP-131 could prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2).

Chemical Information
Molecular Weight 753.81
Formula C34H50F3N9O7
CAS Number 1606994-55-1
Solubility (25°C) Soluble in water
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Sabbah HN, et al. Circ Heart Fail. Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure.

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Keywords: Elamipretide TFA, MTP-131; Bendavia; RX-31; SS-31 supplier, Peptides, inhibitors, activators

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