Monensin Sodium Salt is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium Salt is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium salt causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes.
Exp Cell Res. 2023 Nov 15;432(2):113778.
YTHDF1 shapes “cold” tumor and inhibits CD8+ T cells infiltration and function in breast cancer
Monensin sodium salt purchased from AbMole
J Immunother Cancer. 2023 Oct;11(10):e007230.
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition
Monensin sodium salt purchased from AbMole
Research Square. 2023 May 5.
Breast cancer intrinsic YTHDF1 forms “cold” tumor and inhibits CD8+ T cells infiltration and function
Monensin sodium salt purchased from AbMole
| Molecular Weight | 692.85 |
| Formula | C36H61NaO11 |
| CAS Number | 22373-78-0 |
| Solubility (25°C) | Ethanol 69 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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