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Monensin sodium salt

Cat. No. M6991
Monensin sodium salt Structure
Synonym:

Monensin A sodium salt

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Monensin Sodium Salt is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium Salt is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium salt causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes.

Product Citations
Chemical Information
Molecular Weight 692.85
Formula C36H61NaO11
CAS Number 22373-78-0
Solubility (25°C) Ethanol 69 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lindsley, et al. ACS Chem Neurosci. (3-cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: discovery of a new tool compound with activity in the OSS mouse model of addiction.

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