NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
Cells. 2023 Feb 3;12(3):504.
NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells
NFAT Inhibitor-1 (VIVIT peptide) purchased from AbMole
| Molecular Weight | 1685.94 |
| Formula | C75H120N20O22S |
| CAS Number | 249537-73-3 |
| Form | Solid |
| Solubility (25°C) | Water ≥ 90 mg/mL (ultrasonic) |
| Storage | Store at ≤ -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NFAT Products |
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| Cyclosporin D
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc). |
| (+)-Syringaresinol
(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia. |
| INCA-6
INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). |
Products are for research use only. Not for human use. We do not sell to patients.
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