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NFAT Inhibitor-1 (VIVIT peptide)

Cat. No. M1261
NFAT Inhibitor-1 (VIVIT peptide) Structure

VIVIT peptide; NFAT Inhibitor; ABM-7733

Size Price Availability Quantity
1mg USD 73  USD73 In stock
5mg USD 300  USD300 In stock
10mg USD 555  USD555 In stock
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Quality Control & Documentation
Biological Activity

NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.

Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

Product Citations
Chemical Information
Molecular Weight 1685.94
Formula C75H120N20O22S
CAS Number 249537-73-3
Form Solid
Solubility (25°C) Water ≥ 90 mg/mL (ultrasonic)
Storage Store at ≤ -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Nagamoto-Combs K, et al. J Neurosci. Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells).

[2] Aramburu J, et al. Science. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

Related NFAT Products
Cyclosporin D

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).


(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia.


INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT).

Abmole Inhibitor Catalog

Keywords: NFAT Inhibitor-1 (VIVIT peptide), VIVIT peptide; NFAT Inhibitor; ABM-7733 supplier, NFAT, inhibitors, activators

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