About 13 results found for searched term "NFAT" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1261 | NFAT Inhibitor-1 (VIVIT peptide) | NFAT |
| VIVIT peptide; NFAT Inhibitor; ABM-7733 | ||
| NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. | ||
| M4717 | Usnic-acid | Antibiotic |
| Usnic acid is a lichen secondary metabolite with a unique dibenzofuran skeleton. Usnic acid has excellent anti-cancer and antibacterial properties. Usnic acid significantly inhibited ranKL-mediated osteoclast formation and function by decreasing transcription and translational expression of NFATc1. | ||
| M6826 | INCA-6 | NFAT |
| INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). | ||
| M7875 | KRM-III | Others |
| KRM-III is an inhibitor of T cell antigen receptor (TCR), an inhibitor of phorbol myristate acetate (PMA) /ionomycin-induced nuclear factor of activated T cells (NFAT) activation and T cell proliferation. | ||
| M14721 | KRN2 bromide | Others |
| KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. | ||
| M14801 | 11R-VIVIT TFA | Peptides |
| 11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy. | ||
| M14889 | GNF4877 | DYRK |
| GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||
| M28763 | YZ129 | HSP |
| YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. | ||
| M29299 | (+)-Syringaresinol | NFAT |
| (+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia. | ||
| M30068 | Latanoprost acid | Prostaglandin Receptor |
| Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes. | ||
| M31333 | Kisspeptin-10, human ACETATE | Peptides |
| Kisspeptin-10, human ACETATE is the acetate form of Kisspeptin-10 and is also a potent vasoconstrictor and angiogenesis inhibitor that inhibits tumor metastasis through its receptor GPR54.Kisspeptin-10/GPR54 signaling through NFATc4-mediated BMP2 expression to induces osteoblast differentiation through NFATc4-mediated BMP2 expression. | ||
| M38835 | Picrasidine I | Apoptosis |
| Picrasidine I induces cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1. | ||
| M52844 | 11R-VIVIT | Others |
| 11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. | ||
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