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INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). INCA-6 blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). INCA-6 inhibits NFAT dephosphorylation and nuclear import. INCA-6 also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
| Molecular Weight | 284.31 |
| Formula | C20H12O2 |
| CAS Number | 3519-82-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 2.8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NFAT Products |
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| Cyclosporin D
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc). |
| (+)-Syringaresinol
(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia. |
| NFAT Inhibitor-1 (VIVIT peptide)
NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. |
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Products are for research use only. Not for human use. We do not sell to patients.
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