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Streptozotocin

Cat. No. M2082
Streptozotocin Structure
Synonym:

Streptozocin, STZ

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40  USD40 In stock
200mg USD 60  USD60 In stock
500mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative.

Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.

Product Citations
Customer Product Validations & Biological Datas
Source Macromol Rapid Commun (2018). Figure 4. Streptozotocin (Abmole Bioscience. USA)
Method creating diabetic mice models
Cell Lines diabetic mice
Concentrations -
Incubation Time 24 h
Results Remarkably, the fluorescence intensity of skin treated by non-crosslinked gelatin MNs decreased more sharply compared with crosslinked RS-PGC-MNs.
Source J Drug Target (2018) . Figure 6. Streptozotocin (Abmole Bioscience)
Method intraperitoneal injection
Cell Lines Balb/c mice
Concentrations 100 mg/kg
Incubation Time 48h
Results Figure 6(a-b) shows the in-vivo fluorescence images of Balb/c mice after treatment of different molecular weight of PVA, gelatin, chitosan and HA based MNs array at different time (0, 1, 2, 3, 4, 5, and 8 h) intervals of drug release.
Source J Ind Eng Chem (2017). Figure 3. Streptozotocin (Abmole Bioscience)
Method inject to mice
Cell Lines Female Balb/c mice
Concentrations 10 mg/ml
Incubation Time 48 h
Results The amount of drugs loaded in RSMNs with various length of PLA 182 MNs was approximately 280 ng/patch.
Source RSC Advances(2017). Streptozotocin, Figure 7. (AbMole Bioscience, Shanghai, China)
Method Prior to the experiment, the diabetic model was induced in BALB/c female mice (6–8 weeks old, 16  0.7 g) with streptozotocin (200 mg/kg in sodium citrate buffer, PH 4.5) administrated by intraperitoneal injection aer they were fasted for 6 h only in case of water.
Cell Lines
Concentrations 200 mg/kg
Incubation Time
Results
Chemical Information
Molecular Weight 265.22
Formula C8H15N3O7
CAS Number 18883-66-4
Solubility (25°C) DMSO >100 mg/mL
Water 90 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Semra Acer, et al. Arq Bras Oftalmol. Oxidative stress of crystalline lens in rat menopausal model

[2] Randa A Hadi Diab, et al. Immunol Lett. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies

[3] Yin D, et al. Diabetes. Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

[4] Szkudelski T. Physiol Res. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.

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Keywords: Streptozotocin, Streptozocin, STZ supplier, Animal Modeling, inhibitors, activators


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