Free shipping on all orders over $ 500

Streptozotocin

Cat. No. M2082
Streptozotocin Structure
Synonym:

Streptozocin, STZ

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 63  USD70 In stock
200mg USD 99  USD110 In stock
500mg USD 162  USD180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. Streptozotocin induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo. The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.

Product Citations
Customer Product Validations & Biological Datas
Source Macromol Rapid Commun (2018). Figure 4. Streptozotocin (Abmole Bioscience. USA)
Method creating diabetic mice models
Cell Lines diabetic mice
Concentrations -
Incubation Time 24 h
Results Remarkably, the fluorescence intensity of skin treated by non-crosslinked gelatin MNs decreased more sharply compared with crosslinked RS-PGC-MNs.
Source J Drug Target (2018) . Figure 6. Streptozotocin (Abmole Bioscience)
Method intraperitoneal injection
Cell Lines Balb/c mice
Concentrations 100 mg/kg
Incubation Time 48h
Results Figure 6(a-b) shows the in-vivo fluorescence images of Balb/c mice after treatment of different molecular weight of PVA, gelatin, chitosan and HA based MNs array at different time (0, 1, 2, 3, 4, 5, and 8 h) intervals of drug release.
Source J Ind Eng Chem (2017). Figure 3. Streptozotocin (Abmole Bioscience)
Method inject to mice
Cell Lines Female Balb/c mice
Concentrations 10 mg/ml
Incubation Time 48 h
Results The amount of drugs loaded in RSMNs with various length of PLA 182 MNs was approximately 280 ng/patch.
Source RSC Advances(2017). Streptozotocin, Figure 7. (AbMole Bioscience, Shanghai, China)
Method Prior to the experiment, the diabetic model was induced in BALB/c female mice (6–8 weeks old, 16  0.7 g) with streptozotocin (200 mg/kg in sodium citrate buffer, PH 4.5) administrated by intraperitoneal injection aer they were fasted for 6 h only in case of water.
Cell Lines
Concentrations 200 mg/kg
Incubation Time
Results
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 265.22
Formula C8H15N3O7
CAS Number 18883-66-4
Purity >98%
Solubility DMSO 50 mg/mL
Water 50 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

Oxidative stress of crystalline lens in rat menopausal model
Semra Acer, et al. Arq Bras Oftalmol. Jul-Aug 2016;79(4):222-5. PMID: 27626144.

Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies
Randa A Hadi Diab, et al. Immunol Lett. 2015 Feb;163(2):193-8. PMID: 25573197.

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.
Yin D, et al. Diabetes. 2006 Dec;55(12):3256-63. PMID: 17130468.

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
Szkudelski T. Physiol Res. 2001;50(6):537-46. PMID: 11829314.

Related DNA/RNA Synthesis Products
Methoxyamine HCl

Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.

RK-33

RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity.

Beaucage reagent

Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers.

L189

L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively.

Saccharin 1-methylimidazole

Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Streptozotocin, Streptozocin, STZ supplier, DNA/RNA Synthesis, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.