Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative.
Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.
Acta Biomater. 2023 Sep 13;S1742-7061(23)00544-5.
Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control
Streptozotocin purchased from AbMole
J Cell Physiol. 2023 Jun 3.
RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway
Streptozotocin purchased from AbMole
Molecules. 2023 Jan 18;28(3):968.
Anemoside B4 Exerts Hypoglycemic Effect by Regulating the Expression of GLUT4 in HFD/STZ Rats
Streptozotocin purchased from AbMole
PLoS One. 2023 Jul 19;18(7):e0288876.
Low-dose lipopolysaccharide inducing continuous and obvious increase in urinary protein in hyperglycemic rats and the underlying mechanism
Streptozotocin purchased from AbMole
PLoS One. 2023 Dec 1;18(12):e0294566.
Silencing of topical proline hydroxylase domain 2 promotes the healing of rat diabetic wounds by phosphorylating AMPK
Streptozotocin purchased from AbMole
Drug Deliv Transl Res. 2022 Feb 6.
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery
Streptozotocin purchased from AbMole
Drug Deliv Transl Res. 2022 Feb;12(2):459-471.
Dissolving microneedle rollers for rapid transdermal drug delivery
Streptozotocin purchased from AbMole
Front Pharmacol. 2021 Sep 22;12:719905.
Dissolving Polymer Microneedles for Transdermal Delivery of Insulin
Streptozotocin purchased from AbMole
Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):7.
Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
Streptozotocin purchased from AbMole
Drug Deliv Transl Re. 2021 Apr 13.
Dissolving Microneedle Rollers for Rapid Transdermal Drug Delivery
Streptozotocin purchased from AbMole
Bioengineered. 2021 Dec;12(1):5491-5503.
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
Streptozotocin purchased from AbMole
Sci Adv. 2020 Jul 10;6(28):eaba7260.
A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
Streptozotocin purchased from AbMole
Pharmacol Res. 2020 Jul;157:104831.
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
Streptozotocin purchased from AbMole
2020 Sep.
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
Streptozotocin purchased from AbMole
Macromol Rapid Commun. 2018 May 2;e1800075.
Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin-Crosslinked Gelatin
Streptozotocin purchased from AbMole
Int J Pharm. 2018 Dec 13;556:338-348.
Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.
Streptozotocin purchased from AbMole
J Drug Target. 2018 Jan;16:1-10.
In-vitro and in-vivo assessment of polymer microneedles for controlled transdermal drug delivery
Streptozotocin purchased from AbMole
J Ind Eng Chem. 2017;3311:1–7.
Structural optimization of rapidly separating microneedles for efficient drug delivery
Streptozotocin purchased from AbMole
RSC Advances. 2017;7:15408-15415.
A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
Streptozotocin purchased from AbMole
Molecular Weight | 265.22 |
Formula | C8H15N3O7 |
CAS Number | 18883-66-4 |
Solubility (25°C) | DMSO >100 mg/mL Water 90 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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