Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative.
Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.
Acta Biomater. 2023 Sep 13;S1742-7061(23)00544-5.
Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control
Streptozotocin purchased from AbMole
PLoS One. 2023 Jul 19;18(7):e0288876.
Low-dose lipopolysaccharide inducing continuous and obvious increase in urinary protein in hyperglycemic rats and the underlying mechanism
Streptozotocin purchased from AbMole
Molecules. 2023 Jan 18;28(3):968.
Anemoside B4 Exerts Hypoglycemic Effect by Regulating the Expression of GLUT4 in HFD/STZ Rats
Streptozotocin purchased from AbMole
J Cell Physiol. 2023 Jun 3.
RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway
Streptozotocin purchased from AbMole
Drug Deliv Transl Res. 2022 Feb;12(2):459-471.
Dissolving microneedle rollers for rapid transdermal drug delivery
Streptozotocin purchased from AbMole
Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):7.
Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
Streptozotocin purchased from AbMole
Drug Deliv Transl Res. 2022 Feb 6.
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery
Streptozotocin purchased from AbMole
Front Pharmacol. 2021 Sep 22;12:719905.
Dissolving Polymer Microneedles for Transdermal Delivery of Insulin
Streptozotocin purchased from AbMole
Bioengineered. 2021 Dec;12(1):5491-5503.
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
Streptozotocin purchased from AbMole
Drug Deliv Transl Re. 2021 Apr 13.
Dissolving Microneedle Rollers for Rapid Transdermal Drug Delivery
Streptozotocin purchased from AbMole
2020 Sep.
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
Streptozotocin purchased from AbMole
Pharmacol Res. 2020 Jul;157:104831.
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
Streptozotocin purchased from AbMole
Sci Adv. 2020 Jul 10;6(28):eaba7260.
A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
Streptozotocin purchased from AbMole
Int J Pharm. 2018 Dec 13;556:338-348.
Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.
Streptozotocin purchased from AbMole
Macromol Rapid Commun. 2018 May 2;e1800075.
Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin-Crosslinked Gelatin
Streptozotocin purchased from AbMole
J Drug Target. 2018 Jan;16:1-10.
In-vitro and in-vivo assessment of polymer microneedles for controlled transdermal drug delivery
Streptozotocin purchased from AbMole
J Ind Eng Chem. 2017;3311:1–7.
Structural optimization of rapidly separating microneedles for efficient drug delivery
Streptozotocin purchased from AbMole
RSC Advances. 2017;7:15408-15415.
A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
Streptozotocin purchased from AbMole
Molecular Weight | 265.22 |
Formula | C8H15N3O7 |
CAS Number | 18883-66-4 |
Solubility (25°C) | DMSO >100 mg/mL Water 90 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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N-Butyl-N-(4-hydroxybutyl)nitrosamine
N-Butyl-N-(4-hydroxybutyl)nitrosamine can be used to construct animal models of bladder cancer (BLCA). |
Boromycin
Boromycin is a compound isolated from Streptomyces antibioticus and a boron-containing macrolide antibiotic with potent activity against a number of viruses, gram-positive bacteria and protozoan parasites. It can be used to induce a mouse model of pulmonary fibrosis and can be used in malaria-related studies. |
Dextrose iron
Dextrose iron can be used to construct animal models of iron overload. |
Prednisone acetate
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Carrageenan
Carrageenan is a biochemical reagent that can be used to construct animal models of chronic non-bacterial prostatitis, models of synovitis, and models of prostatitis. |
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