Streptozotocou (STZ) is a kind of glucosamine - nitrosourea derivative.
Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.
Drug Deliv Transl Res. 2022 Feb;12(2):459-471.
Dissolving microneedle rollers for rapid transdermal drug delivery
Streptozotocin purchased from AbMole
Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):7.
Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
Streptozotocin purchased from AbMole
Drug Deliv Transl Res. 2022 Feb 6.
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery
Streptozotocin purchased from AbMole
Front Pharmacol. 2021 Sep 22;12:719905.
Dissolving Polymer Microneedles for Transdermal Delivery of Insulin
Streptozotocin purchased from AbMole
Bioengineered. 2021 Dec;12(1):5491-5503.
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
Streptozotocin purchased from AbMole
Drug Deliv Transl Re. 2021 Apr 13.
Dissolving Microneedle Rollers for Rapid Transdermal Drug Delivery
Streptozotocin purchased from AbMole
2020 Sep.
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
Streptozotocin purchased from AbMole
Pharmacol Res. 2020 Jul;157:104831.
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
Streptozotocin purchased from AbMole
Sci Adv. 2020 Jul 10;6(28):eaba7260.
A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
Streptozotocin purchased from AbMole
Int J Pharm. 2018 Dec 13;556:338-348.
Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.
Streptozotocin purchased from AbMole
Macromol Rapid Commun. 2018 May 2;e1800075.
Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin-Crosslinked Gelatin
Streptozotocin purchased from AbMole
J Drug Target. 2018 Jan;16:1-10.
In-vitro and in-vivo assessment of polymer microneedles for controlled transdermal drug delivery
Streptozotocin purchased from AbMole
J Ind Eng Chem. 2017;3311:1–7.
Structural optimization of rapidly separating microneedles for efficient drug delivery
Streptozotocin purchased from AbMole
RSC Advances. 2017;7:15408-15415.
A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
Streptozotocin purchased from AbMole
Molecular Weight | 265.22 |
Formula | C8H15N3O7 |
CAS Number | 18883-66-4 |
Solubility (25°C) | DMSO 50 mg/mL Water 50 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related DNA/RNA Synthesis Products |
---|
D-I03
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. |
Bractoppin
Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain with IC50 of 74 nM. Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. |
Plitidepsin
Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research. |
Tofersen
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce SOD1 protein synthesis. Tofersen can be used in amyotrophic lateral sclerosis (ALS) research. |
ART812
ART812 is an orally effective DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 had an IC50 value of 240 nM for cell-based microhomologous mediated end-junction (MMEJ). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.