Streptozotocou (STZ) is a kind of glucosamine - nitrosourea derivative.
Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.
Front Pharmacol. 2021 Sep 22;12:719905.
Dissolving Polymer Microneedles for Transdermal Delivery of Insulin
Streptozotocin purchased from AbMole
Bioengineered. 2021 Dec;12(1):5491-5503.
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
Streptozotocin purchased from AbMole
Drug Deliv Transl Re. 2021 Apr 13.
Dissolving Microneedle Rollers for Rapid Transdermal Drug Delivery
Streptozotocin purchased from AbMole
2020 Sep.
Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
Streptozotocin purchased from AbMole
Pharmacol Res. 2020 Jul;157:104831.
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
Streptozotocin purchased from AbMole
Sci Adv. 2020 Jul 10;6(28):eaba7260.
A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
Streptozotocin purchased from AbMole
Int J Pharm. 2018 Dec 13;556:338-348.
Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.
Streptozotocin purchased from AbMole
Macromol Rapid Commun. 2018 May 2;e1800075.
Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin-Crosslinked Gelatin
Streptozotocin purchased from AbMole
J Drug Target. 2018 Jan;16:1-10.
In-vitro and in-vivo assessment of polymer microneedles for controlled transdermal drug delivery
Streptozotocin purchased from AbMole
J Ind Eng Chem. 2017;3311:1–7.
Structural optimization of rapidly separating microneedles for efficient drug delivery
Streptozotocin purchased from AbMole
RSC Advances. 2017;7:15408-15415.
A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
Streptozotocin purchased from AbMole
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Molecular Weight | 265.22 |
Formula | C8H15N3O7 |
CAS Number | 18883-66-4 |
Purity | >98% |
Solubility | DMSO 50 mg/mL Water 50 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
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Tempo
Tempo is a nitric oxide radical and a selective scavenging agent of ROS that disambiguates superoxides in catalytic cycles. Tempo can induce DNA strand breaking and can be used as an organic catalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects. |
NSC 617145
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IMP-1088
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Methoxyamine HCl
Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. |
RK-33
RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity. |
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