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Benzbromarone

Cat. No. M2440
Benzbromarone Structure
Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Benzbromarone is a URAT1 inhibitor that inhibits MDCKII cells over-expressing URAT1 with an IC50 of 0.190 μM. Benzbromarone is also a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.

Chemical Information
Molecular Weight 424.08
Formula C17H12Br2O3
CAS Number 3562-84-3
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Esraa Abdel-Nassir Abdel-Razek, et al. Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression

[2] No authors listed. Benzbromarone

[3] Valderilio Feij Azevedo, et al. Benzbromarone in the treatment of gout

[4] Peng Sun, et al. Benzbromarone aggravates hepatic steatosis in obese individuals

[5] Ming-Han H Lee, et al. A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?

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