Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test: less than 0.001 ng/µg (0.01 EU/µg)
Apparent molecular weight: 17kda, reduction conditions
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months.
Bioactivity: Interleukin 2 (IL 2), also known as T-cell growth factor, is a member of a family of cytokines that includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of the family has a four-helix bundle. Il-2 signaling is transmitted through the IL-2 receptor, a complex of tree-like subunits called alpha, beta, and gamma. Il-2rγ is shared by cytokine receptors from all members of the cytokine family. The identity of mature mouse IL-2 with human IL-2 and rat IL-2 was 56% and 73%, respectively. Il-2 is produced by CD4+ T cells, CD8+ T cells, γδT cells, B cells, dendritic cells and eosinophils, and plays an important role in key functions of the immune system, tolerance and immunity, mainly through its powerful stimulatory activity on T cells. Thus, IL-2 may be a key cytokine that naturally suppresses autoimmunity.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Purity||>95% , Endotoxin < 0.01 EU/µg|
|Solubility||It is not recommended to reconstitute to a concentration less than 100μg/ml.|
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