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Recombinant Mouse IL-2 (E.coli)

Cat. No. M19999
Recombinant Mouse IL-2 (E.coli) Structure
Synonym:

aldesleukin; interleukin 2; interleukin-2

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50ug USD 368  USD460 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.01 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Mouse
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test: less than 0.001 ng/µg (0.01 EU/µg)
Apparent molecular weight: 17kda, reduction conditions
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months.


Bioactivity: Interleukin 2 (IL 2), also known as T-cell growth factor, is a member of a family of cytokines that includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of the family has a four-helix bundle. Il-2 signaling is transmitted through the IL-2 receptor, a complex of tree-like subunits called alpha, beta, and gamma. Il-2rγ is shared by cytokine receptors from all members of the cytokine family. The identity of mature mouse IL-2 with human IL-2 and rat IL-2 was 56% and 73%, respectively. Il-2 is produced by CD4+ T cells, CD8+ T cells, γδT cells, B cells, dendritic cells and eosinophils, and plays an important role in key functions of the immune system, tolerance and immunity, mainly through its powerful stimulatory activity on T cells. Thus, IL-2 may be a key cytokine that naturally suppresses autoimmunity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.01 EU/µg
Solubility It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
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Keywords: Recombinant Mouse IL-2 (E.coli), aldesleukin; interleukin 2; interleukin-2 supplier, Cytokines, inhibitors

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