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Recombinant Mouse IL-2 (E.coli)

Cat. No. M19999
Recombinant Mouse IL-2 (E.coli) Structure

aldesleukin; interleukin 2; interleukin-2

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50ug USD 460  USD460 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.01 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Mouse
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test: less than 0.001 ng/µg (0.01 EU/µg)
Apparent molecular weight: 17kda, reduction conditions
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months.

Bioactivity: Interleukin 2 (IL 2), also known as T-cell growth factor, is a member of a family of cytokines that includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of the family has a four-helix bundle. Il-2 signaling is transmitted through the IL-2 receptor, a complex of tree-like subunits called alpha, beta, and gamma. Il-2rγ is shared by cytokine receptors from all members of the cytokine family. The identity of mature mouse IL-2 with human IL-2 and rat IL-2 was 56% and 73%, respectively. Il-2 is produced by CD4+ T cells, CD8+ T cells, γδT cells, B cells, dendritic cells and eosinophils, and plays an important role in key functions of the immune system, tolerance and immunity, mainly through its powerful stimulatory activity on T cells. Thus, IL-2 may be a key cytokine that naturally suppresses autoimmunity.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jianlin Chen, et al. Biology (Basel). Co-Expression of Pig IL-2 and Fusion Bovine Cathelicidin Gene by Recombinant Plasmids in Yeast and Their Promotion of Mouse Antibacterial Defense

[2] Elham Adabi, et al. Iran Biomed J. Evaluation of an Albumin-Binding Domain Protein Fused to Recombinant Human IL-2 and Its Effects on the Bioactivity and Serum Half-Life of the Cytokine

[3] Can Xu, et al. World J Gastroenterol. Construction of recombinant attenuated Salmonella typhimurium DNA vaccine expressing H pylori ureB and IL-2

[4] V Bronte, et al. J Immunol. IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases

[5] C M Roifman, et al. Cell Immunol. Functional comparison of recombinant interleukin 2 (IL-2) with IL-2-containing preparations derived from cultured cells

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Keywords: Recombinant Mouse IL-2 (E.coli), aldesleukin; interleukin 2; interleukin-2 supplier, Recombinant Proteins, inhibitors, activators

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