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Nicotinamide

Cat. No. M4896
Nicotinamide Structure
Synonym:

Vitamin B3

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40.5  USD45 In stock
500mg USD 36  USD40 In stock
1g USD 49.5  USD55 In stock
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Quality Control
Biological Activity

Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 122.12
Formula C6H6N2O
CAS Number 98-92-0
Purity 99.78%
Solubility DMSO 30 mg/mL
Water 30 mg/mL
Storage -20°C, protect from light, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nicotinamide, Vitamin B3 supplier, Sirtuin, inhibitors

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