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Nicotinamide

Cat. No. M4896
Nicotinamide Structure
Synonym:

Vitamin B3; Nicotinic acid amide; Niacinamide

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 45  USD45 In stock
500mg USD 40  USD40 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions.

Product Citations
Chemical Information
Molecular Weight 122.12
Formula C6H6N2O
CAS Number 98-92-0
Solubility (25°C) DMSO 30 mg/mL
Water 30 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mario Mehmel, et al. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses

[2] Eun Seong Hwang, et al. Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment

[3] Luca Fania, et al. Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention

[4] Eun Seong Hwang, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells

[5] Frances M Walocko, et al. The role of nicotinamide in acne treatment

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Keywords: Nicotinamide, Vitamin B3; Nicotinic acid amide; Niacinamide supplier, Sirtuin, inhibitors, activators


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