About 6 results found for searched term "98-92-0" (0.202 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2789 | K02288 | ALK |
| K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. | ||
| M4896 | Nicotinamide | Sirtuin |
| Vitamin B3; Nicotinic acid amide; Niacinamide | ||
| Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. | ||
| M29079 | Mefatinib | c-Met |
| Mifanertinib dimaleate | ||
| Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity. | ||
| M5335 | PF-4989216 | PI3K |
| PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively. | ||
| M21077 | BMS-986176 | Others |
| LX-9211; AAK1-IN-1 | ||
| BMS-986176/LX-9211 is an orally administered, CNS-penetrating AAK1 kinase inhibitor with an IC50 of 2 nM that is being developed for use in neuropathic pain studies. | ||
| M54696 | DGY-09-192 | PROTAC |
| DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. | ||
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