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BMS-986176

Cat. No. M21077

All AbMole products are for research use only, cannot be used for human consumption.

BMS-986176 Structure
Synonym:

LX-9211; AAK1-IN-1

Size Price Availability Quantity
5mg USD 440  USD440 In stock
10mg USD 800  USD800 In stock
25mg USD 1600  USD1600 In stock
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Quality Control & Documentation
Biological Activity

BMS-986176/LX-9211 is an orally administered, CNS-penetrating AAK1 kinase inhibitor with an IC50 of 2 nM that is being developed for use in neuropathic pain studies.

Chemical Information
Molecular Weight 385.40
Formula C19H23F4N3O
CAS Number 1815613-42-3
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Xin Xin, et al. Eur J Med Chem. Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases

[2] Guanglin Luo, et al. J Med Chem. Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain

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Keywords: BMS-986176, LX-9211; AAK1-IN-1 supplier, inhibitors, activators

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