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K02288

Cat. No. M2789
K02288 Structure
Size Price Availability Quantity
10mg USD 160  USD160 In stock
50mg USD 540  USD540 In stock
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Quality Control
Biological Activity

K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 352.38
Formula C20H20N2O4
CAS Number 1431985-92-0
Purity 100.00%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

[1] D Mattar, et al. Modulatory effects of TGF-β1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary

[2] Nathan F Denton, et al. Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis

[3] Hyoin Kim, et al. Rac1 promotes chondrogenesis by regulating STAT3 signaling pathway

[4] Georgina Kerr, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

[5] Caroline E Sanvitale, et al. A new class of small molecule inhibitor of BMP signaling

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Keywords: K02288 supplier, ALK, inhibitors

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