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K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
Molecular Weight | 352.38 |
Formula | C20H20N2O4 |
CAS Number | 1431985-92-0 |
Solubility (25°C) | DMSO 50 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Hyoin Kim, et al. Rac1 promotes chondrogenesis by regulating STAT3 signaling pathway
[5] Caroline E Sanvitale, et al. A new class of small molecule inhibitor of BMP signaling
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ALKBH5-IN-3
ALKBH5-IN-3 is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells. |
F-1
F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50 values of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. |
TL13-22
TL13-22 is a negative control for TL13-12 and a potent ALK inhibitor with an IC50 of 0.54 nM. |
TL13-110
TL13-110 is a negative control for TL13-112 and a potent ALK inhibitor with an IC50 of 0.34 nM. |
ALK inhibitor 2
ALK inhibitor 2 is a potent pyrimidin ALK inhibitor. |
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Products are for research use only. Not for human use. We do not sell to patients.
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