About 30 results found for searched term "ALK" (0.074 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1859 | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M2109 | AZD3463 | ALK |
| ALK/IGF1R inhibitor | ||
| AZD3463 is a novel ALK/IGF1R inhibitor with IC50 value of 22 nM. | ||
| M5309 | ALK-IN-1 | ALK |
| ALK-IN-1 is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR. | ||
| M11157 | Alkaline phosphatase (E. coli) | Metabolite/Endogenous Metabolite |
| Alkaline phosphatase is a membrane-binding glycoprotein that catalyzes the hydrolysis of monos phosphate esters at alkaline pH. Alkaline phosphatase can be used for molecular biology and enzyme-free analysis. | ||
| M14877 | ALK inhibitor 1 | ALK |
| ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). | ||
| M14942 | ALK2-IN-2 | TGF-β Receptor |
| ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. | ||
| M18129 | β,β-Dimethylacrylalkannin | HIF |
| Arnebin 1 | ||
| β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells. | ||
| M18175 | β, β-dimethyl-acrylalkannin | Others |
| β, β-dimethyl-acrylalkannin | ||
| M20931 | Benzalkonium chloride | Animal Modeling |
| Benzalkonium chloride is a cationic surface-acting agent containing the quaternary ammonium group | ||
| M20956 | Diroximel Fumarete | Keap1-Nrf2 |
| ALKS-8700; BIIB098; DRF | ||
| Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Diroximel fumarate is a Nrf2 activator. | ||
| M24696 | Ascrinvacumab | ALK |
| Anti-ACVRL1/ALK-1 Reference Antibody; PF-03446962 | ||
| Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC). | ||
| M25078 | Nemvaleukin alfa | IL Receptor/Related |
| ALKS 4230; RDB-1450 | ||
| Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer. | ||
| M55622 | Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | ||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | ||
| M28040 | ALK4290 | CCR |
| AKST4290 | ||
| ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism. | ||
| M28253 | Ac4GlcNAlk | PROTAC Linker |
| Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M28499 | ALK kinase inhibitor-1 | ALK |
| ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor. | ||
| M28954 | Iruplinalkib | ALK |
| WX-0593 | ||
| Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement. | ||
| M28969 | Envonalkib citrate | ALK |
| Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer. | ||
| M29396 | Ficonalkib | ALK |
| Ficonalkib is a potent inhibitor of Anaplastic lymphoma kinase (ALK), the tyrosine kinase receptor. Ficonalkib, can be used as an antineoplastic agent. | ||
| M29638 | ARS-1323-alkyne | Ras |
| ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells. | ||
| M30225 | (Rac)-Arnebin 1 | HIF |
| (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin | ||
| (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity. | ||
| M30227 | (-)-Alkannin | Apoptosis |
| (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway. | ||
| M30931 | IA-Alkyne | TRP Channel |
| Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide | ||
| IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. | ||
| M30988 | Alkynyl Palmitic Acid | PROTAC Linker |
| Alk-C16 | ||
| Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M38649 | Cetalkonium chloride | Antibiotic |
| Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. | ||
| M39557 | Lauryl benzalkonium chloride | Others |
| Lauryl benzalkonium chloride is a cationic surfactant. | ||
| M43106 | GALK1-IN-1 | Others |
| GALK1-IN-1 is a galactokinase inhibitor (IC50: 4.2129 μM). | ||
| M43121 | EN219-alkyne | Others |
| EN219-alkyne is an alkyne-functionalized EN219 probe. | ||
| M43471 | ALK2-IN-5 | ALK |
| ALK2-IN-5, pyrazolopyrimidine compound, is an ALK2 inhibitor. | ||
| M43962 | Itaconate-alkyne | Others |
| ITalk | ||
| Itaconate-alkyne is a specific bioorthogonal probe and functional analog of Itaconation, which has similar anti-inflammatory activity to Itaconic acid, and can label the true target of Itaconic acid for quantitative and localized Itaconic acid chemistry proteomics analysis in living cells. In addition, Itaconate-alkyne is also a click chemistry containing an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. | ||
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