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Diroximel Fumarete

Cat. No. M20956

All AbMole products are for research use only, cannot be used for human consumption.

Diroximel Fumarete Structure
Synonym:

ALKS-8700; BIIB098; DRF

Size Price Availability Quantity
5mg USD 108  USD108 In stock
10mg USD 155  USD155 In stock
50mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Diroximel fumarate is a Nrf2 activator which can alleviate MGO-induced pain hypersensitivity.

Chemical Information
Molecular Weight 255.22
Formula C11H13NO6
CAS Number 1577222-14-0
Solubility (25°C) DMSO 100 mg/mL
Water 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sibyl Wray, et al. Adv Ther. Efficacy and Safety Outcomes with Diroximel Fumarate After Switching from Prior Therapies or Continuing on DRF: Results from the Phase 3 EVOLVE-MS-1 Study

[2] No authors listed. Diroximel Fumarate

[3] Robert T Naismith, et al. CNS Drugs. Diroximel Fumarate Demonstrates an Improved Gastrointestinal Tolerability Profile Compared with Dimethyl Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III EVOLVE-MS-2 Study

[4] Robert T Naismith, et al. Mult Scler. Diroximel fumarate (DRF) in patients with relapsing-remitting multiple sclerosis: Interim safety and efficacy results from the phase 3 EVOLVE-MS-1 study

[5] No authors listed. Multiple Sclerosis Agents

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Keywords: Diroximel Fumarete, ALKS-8700; BIIB098; DRF supplier, Keap1-Nrf2, inhibitors, activators

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