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Luteolin (Luteoline) is a flavanoid that can induce cell apoptosis and cell cycle arrest in several cancer cell lines. Luteolin (Luteoline) is also a potent Nrf2 inhibitor.
Luteolin (0-160 µM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner.
In vivo, Luteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet.
| Molecular Weight | 286.24 |
| Formula | C15H10O6 |
| CAS Number | 491-70-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Fabian Gendrisch, et al. Luteolin as a modulator of skin aging and inflammation
[2] Muhammad Imran, et al. Luteolin, a flavonoid, as an anticancer agent: A review
[5] Yong Lin, et al. Luteolin, a flavonoid with potential for cancer prevention and therapy
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